Publications and training
November 1984. Expoquimia. Barcelona.“3as Jornadas de Análisis Instrumental ”Analysis of Polycyclic Aromatic Hydrocarbons in public drinking water. (N.Salvatella Sociedad General de Aguas de Barcelona and A.Tintó, Cerba Internacional S.A.).
Pharmeuropa Vol 4, nº2, 1992. Determination of Residual Solvents in Bulk Pharmaceutical Products by Manual Static Head-Space Gas Chromatography.
Spanish Patent: “ Un accesorio manual para la técnica de espacio de cabeza-cromatografia de gases” P9100628. Application date: 13 February 1991. Grant date:12 June 1992.
A. Tintó-Moliner & M. Martin, 2020. Quantitative weight of evidence method for combining predictions of quantitative structure-activity relationship models. 31. SAR and QSAR in Environmental Research., pp 261-279. DOI: 10.1080/1062936X.2020.1725116.
ICH M7 Guideline
Practical aspects of the implementation of the ICH M7 guideline. Lecture given by Antoni Tintó Moliner in the Conference about Evaluation of genotoxic impurities in accordance with the ICH M7, organized by the Spanish Association of Pharmaceutical Industry (AEFI). Barcelona, May 25th, 2017.
THE LESSON OF WILLIAM HORWITZ
Any analytical determination is associated with uncertainty and its knowledge is necessary to determine the meaning of the numerical result of the analysis. For example, saying that a reference material has a purity of 98.0% is only a part of the result. If we know the uncertainty of the result, for example if it were ± 2,0 %, then it can be said that the purity is in the interval 96.0-100% and so we will know for what uses we can use this material.
William Horwitz found a simple relationship describing the variation between the accuracy and concentration of the ANALYTE in cross-laboratory trials.
The equation of William Horwitz is:
RSDR (%) = 2 exp (1-0.5 log10 C)
Where RSDR is the relative standard deviation and C is the concentration of the analyte. This relationship allows us to know the expected uncertainty according to the concentration of the analyte that want to determine. For example, if the concentration of the analyte is 1,00 ppm, it is to be expected that the uncertainty will be 16%. 24 years later Lisinger and Josephs established that the approach made by Horwitz it is not compatible with the definition of uncertainty described in ISO 17025. The EURACHEM/CITAC 2012 guide describes the new approach and it is the procedure to be followed to determine the uncertainty of a quantitative analysis. As many variables (weight, volumes, etc.) are involved, uncertainty is associated with a particular determination.
We offer advice on the qualification of the uncertainty of a work pattern with respect to a certified reference material and on any other question related to the uncertainty of the measurements of chemical parameters.